Only one case of seizure was reported with mirtazapine, a newer tetracyclic antidepressant, during premarketing trials involving nearly 2800 patients. However, the drug has not been evaluated in controlled studies of patients with a history of seizures. Therapy with mirtazapine should be administered cautiously in such patients. Describes the medication mirtazapine (Remeron, Soltab), a drug used for the treatment of depression and posttraumatic stress disorder (PTSD). Side effects and drug interactions are included in the information. Read more about the prescription drug mirtazapine (Remeron, Soltab). seizure medicine - carbamazepine, phenytoin. Other drugs may interact with mirtazapine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Psychiatric illnesses are commonly found in patients with epilepsy, with major depressive disorder (MDD) being the single most common psychiatric disorder. 1 In patients with comorbid epilepsy and depressive illnesses, the presence of depressive symptoms has been classified temporally with regard to the seizure. Ever since I tried to off myself using Mirtazapine in July '10 i've been experiencing a lot of Muscle Spazms. jolt like feelings, seizure like things that I experienced when I tried to off myself but to a lesser degree. Because depression is common in the general population and occurs even more often in patients with epilepsy (up to 50%, depending on the screening tool used39), and because treatment of depression usually requires long-term drug treatment, the choice of antidepressant medication must be made carefully, taking into account the possible effect on seizure threshold. Introduction. Mirtazapine is increasingly used in the treatment of depression and other psychiatric conditions. The incidence of seizures associated with Mirtazapine use is low. Seizure disorder is found among people who take Mirtazapine, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Paracetamol, and have High blood pressure. Summary. Epilepsy is found among people who take Mirtazapine, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Paracetamol, and have High blood pressure. Mirtazapine is an antidepressant medicine. It's used to treat depression and sometimes obsessive compulsive disorder and anxiety disorders. Mirtazapine is available only on prescription.